Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data

BACKGROUND: Long non-coding RNAs (lncRNAs) are typically expressed at low levels and are inherently highly variable. This is a fundamental challenge for differential expression (DE) analysis. In this study, the performance of 25 pipelines for testing DE in RNA-seq data is comprehensively evaluated,...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Assefa, Alemu Takele, De Paepe, Katrijn, Everaert, Celine, Mestdagh, Pieter, Thas, Olivier, Vandesompele, Jo
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058388/
https://ncbi.nlm.nih.gov/pubmed/30041657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1466-5
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