Does ATRX germline variation predispose to osteosarcoma? Three additional cases of osteosarcoma in two ATR-X syndrome patients

Osteosarcoma is the most common malignant bone tumor in adolescents and young adults. Most osteosarcomas are sporadic but the risk of osteosarcoma is also increased by germline variants in TP53, RB1 and RECQL4 genes. ATRX germline variations are responsible for the rare genetic disorder X-linked alp...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Masliah-Planchon, Julien, Lévy, Dominique, Héron, Delphine, Giuliano, Fabienne, Badens, Catherine, Fréneaux, Paul, Galmiche, Louise, Guinebretierre, Jean-Marc, Cellier, Cécile, Waterfall, Joshua J., Aït-Raïs, Khadija, Pierron, Gaëlle, Glorion, Christophe, Desguerre, Isabelle, Soler, Christine, Deville, Anne, Delattre, Olivier, Michon, Jean, Bourdeaut, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057977/
https://ncbi.nlm.nih.gov/pubmed/29706636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-018-0147-x
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