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Foxo3 promotes apoptosis of BCR-stimulated immature B cells, thus limiting the window for receptor editing
Central tolerance checkpoints are critical for the elimination of autoreactive B cells and the prevention of autoimmunity. When autoreactive B cells encounter their antigen at the immature B cell stage, BCR crosslinking induces receptor editing, followed by apoptosis if edited cells remain autoreact...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6057821/ https://ncbi.nlm.nih.gov/pubmed/29950509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701070 |
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