Interleukin-21 Induces Short-Lived Effector CD8(+) T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice

Interleukin 21 (IL-21) is a pleiotropic common cytokine receptor γ chain cytokine that promotes the effector functions of NK cells and CD8(+) T cells and inhibits CD8(+) T cell exhaustion during chronic infection. We found that the absolute number of short-lived effector CD8(+) T cells (SLECs) (KLRG...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Infect Immun
Prif Awduron: Noguchi, Naoto, Nakamura, Risa, Hatano, Shinya, Yamada, Hisakata, Sun, Xun, Ohara, Naoya, Yoshikai, Yasunobu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Bacterial Infections
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056876/
https://ncbi.nlm.nih.gov/pubmed/29844233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00147-18
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