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Mitochondrial DNA replication in mammalian cells: overview of the pathway

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help...

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Bibliographic Details
Published in:Essays Biochem
Main Author: Falkenberg, Maria
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056714/
https://ncbi.nlm.nih.gov/pubmed/29880722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/EBC20170100
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