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How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion
Dengue virus (DV) is a compact, icosahedrally symmetric, enveloped particle, covered by 90 dimers of envelope protein (E), which mediates viral attachment and membrane fusion. Fusion requires a dimer-to-trimer transition and membrane engagement of hydrophobic ‘fusion loops’. We previously characteri...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6056230/ https://ncbi.nlm.nih.gov/pubmed/29999491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36461 |
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