Increasing Circulating Sphingosine-1-Phosphate Attenuates Lung Injury During Ex Vivo Lung Perfusion

BACKGROUND: Sphingosine-1-phosphate (S1P) regulates endothelial barrier integrity and promotes cell survival and proliferation. We hypothesized that upregulation of S1P during ex vivo lung perfusion (EVLP) would attenuate acute lung injury and improve graft function. METHODS: C57BL/6 mice (n=4-8/gro...

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Detalhes bibliográficos
Publicado no:J Thorac Cardiovasc Surg
Main Authors: Mehaffey, J. Hunter, Charles, Eric J., Narahari, Adishesh K., Schubert, Sarah, Laubach, Victor E., Teman, Nicholas R, Lynch, Kevin R., Kron, Irving L., Sharma, Ashish K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056006/
https://ncbi.nlm.nih.gov/pubmed/29609890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2018.02.090
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