Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ(12)‐Prostaglandin J(3)

Re‐investigation of the l‐proline catalyzed double aldol cascade dimerization of succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of stereoselective prostaglandin synthesis, is reported. The yield of this process has been more than doubled, from 14 % to a...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Pelšs, Andrejs, Gandhamsetty, Narasimhulu, Smith, James R., Mailhol, Damien, Silvi, Mattia, Watson, Andrew J. A., Perez‐Powell, Isabel, Prévost, Sébastien, Schützenmeister, Nina, Moore, Peter R., Aggarwal, Varinder K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055629/
https://ncbi.nlm.nih.gov/pubmed/29774967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201802498
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