The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

BACKGROUND: Alzheimer’s disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of Aβ. Our previous research confirmed that Nogo-66 binding to Nogo receptors (NgR) expressed on microglia...

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Publicat a:J Neuroinflammation
Autors principals: Fang, Yinquan, Wang, Jianing, Yao, Lemeng, Li, Chenhui, Wang, Jing, Liu, Yuan, Tao, Xia, Sun, Hao, Liao, Hong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054753/
https://ncbi.nlm.nih.gov/pubmed/30029608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1250-1
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