Llwytho...
The BDNF Val66Met prodomain disassembles dendritic spines altering fear extinction circuitry and behavior
A human variant in the BDNF gene (Val66Met; rs6265) is associated with impaired fear extinction. Using super-resolution imaging, we demonstrate that the BDNF Met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. In vivo, ventral CA1 (vCA1) hippocampal neurons un...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Neuron |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054457/ https://ncbi.nlm.nih.gov/pubmed/29909994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.05.024 |
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