The BDNF Val66Met prodomain disassembles dendritic spines altering fear extinction circuitry and behavior

A human variant in the BDNF gene (Val66Met; rs6265) is associated with impaired fear extinction. Using super-resolution imaging, we demonstrate that the BDNF Met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. In vivo, ventral CA1 (vCA1) hippocampal neurons un...

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Detaylı Bibliyografya
Yayımlandı:Neuron
Asıl Yazarlar: Giza, Joanna I., Kim, Jihye, Meyer, Heidi C., Anastasia, Agustin, Dincheva, Iva, Zheng, Crystal I., Lopez, Katherine, Bains, Henrietta, Yang, Jianmin, Bracken, Clay, Liston, Conor, Jing, Deqiang, Hempstead, Barbara L., Lee, Francis S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054457/
https://ncbi.nlm.nih.gov/pubmed/29909994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.05.024
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