The BDNF Val66Met prodomain disassembles dendritic spines altering fear extinction circuitry and behavior

A human variant in the BDNF gene (Val66Met; rs6265) is associated with impaired fear extinction. Using super-resolution imaging, we demonstrate that the BDNF Met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. In vivo, ventral CA1 (vCA1) hippocampal neurons un...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuron
Prif Awduron: Giza, Joanna I., Kim, Jihye, Meyer, Heidi C., Anastasia, Agustin, Dincheva, Iva, Zheng, Crystal I., Lopez, Katherine, Bains, Henrietta, Yang, Jianmin, Bracken, Clay, Liston, Conor, Jing, Deqiang, Hempstead, Barbara L., Lee, Francis S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054457/
https://ncbi.nlm.nih.gov/pubmed/29909994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.05.024
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