In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

BACKGROUND: A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent studies showed that ascorbate may upregulate the activity of TET enzymes in culture...

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Publicado en:J Transl Med
Autores principales: Starczak, Marta, Zarakowska, Ewelina, Modrzejewska, Martyna, Dziaman, Tomasz, Szpila, Anna, Linowiecka, Kinga, Guz, Jolanta, Szpotan, Justyna, Gawronski, Maciej, Labejszo, Anna, Liebert, Ariel, Banaszkiewicz, Zbigniew, Klopocka, Maria, Foksinski, Marek, Gackowski, Daniel, Olinski, Ryszard
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053776/
https://ncbi.nlm.nih.gov/pubmed/30029654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1581-9
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