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Epicutaneous administration of the pattern recognition receptor agonist polyinosinic–polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells
Together with keratinocytes (KCs) and the dense network of Langerhans cells (LCs), the epidermis is an ideal portal for vaccine delivery. Pattern recognition receptor agonists, in particular polyinosinic–polycytidylic acid [p(I:C)], are promising adjuvant candidates for therapeutic vaccination to ge...
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| Udgivet i: | FASEB J |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Federation of American Societies for Experimental Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6053315/ https://ncbi.nlm.nih.gov/pubmed/29509510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701090R |
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