KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

Kaposi’s sarcoma (KS) herpesvirus (KSHV) causes KS, an angiogenic AIDS-associated spindle-cell neoplasm, by activating host oncogenic signaling cascades through autocrine and paracrine mechanisms. Tyrosine kinase receptor (RTK) proteomic arrays, identified PDGF receptor-alpha (PDGFRA) as the predomi...

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Vydáno v:PLoS Pathog
Hlavní autoři: Cavallin, Lucas E., Ma, Qi, Naipauer, Julian, Gupta, Sachin, Kurian, Mani, Locatelli, Paola, Romanelli, Paolo, Nadji, Mehrdad, Goldschmidt-Clermont, Pascal J., Mesri, Enrique A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053240/
https://ncbi.nlm.nih.gov/pubmed/29985958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007175
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