miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling

To investigate the role of miR-122 in the development and regression of non-alcoholic fatty liver disease (NAFLD) in vitro, we used multicellular 3D human liver organoids developed in our laboratory. These organoids consist of primary human hepatocytes, Kupffer cells, quiescent stellate cells and li...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Sendi, Hossein, Mead, Ivy, Wan, Meimei, Mehrab-Mohseni, Marjan, Koch, Kenneth, Atala, Anthony, Bonkovsky, Herbert L., Bishop, Colin E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053181/
https://ncbi.nlm.nih.gov/pubmed/30024933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200847
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