Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

The purpose of this study was to determine whether blocking of G protein βγ (Gβγ) signaling halts heart failure (HF) progression by macrophage phenotype manipulation. Cardiac Gβγ signaling plays a crucial role in HF pathogenesis. Previous data suggested that inhibiting Gβγ signaling reprograms T hel...

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Pubblicato in:PLoS One
Autori principali: Karuppagounder, Vengadeshprabhu, Bajpai, Anamika, Meng, Shu, Arumugam, Somasundaram, Sreedhar, Remya, Giridharan, Vijayasree V., Guha, Ashrith, Bhimaraj, Arvind, Youker, Keith A., Palaniyandi, Suresh S., Karmouty-Quintana, Harry, Kamal, Fadia, Spiller, Kara L., Watanabe, Kenichi, Thandavarayan, Rajarajan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053176/
https://ncbi.nlm.nih.gov/pubmed/30024944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200697
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