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Bioresponsive Microneedles with a Sheath Structure for H(2)O(2) and pH Cascade-Triggered Insulin Delivery

Self-regulating glucose-responsive insulin delivery systems have great potential to improve clinical outcomes and quality of life among patients with diabetes. Herein, an H(2)O(2)-labile and positively charged amphiphilic diblock copolymer is synthesized, which is subsequently used to form nano-size...

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Détails bibliographiques
Publié dans:Small
Auteurs principaux: Zhang, Yuqi, Wang, Jinqiang, Yu, Jicheng, Wen, Di, Kahkoska, Anna R., Lu, Yue, Zhang, Xudong, Buse, John B., Gu, Zhen
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053064/
https://ncbi.nlm.nih.gov/pubmed/29479811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201704181
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