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Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos
Caseinolytic peptidase P mediates degradation of unfolded mitochondrial proteins and activates mitochondrial unfolded protein response (mtUPR) to maintain protein homeostasis. Clpp (−/−) female mice generate a lower number of mature oocytes and two‐cell embryos, and no blastocysts. Clpp (−/−) oocyte...
में बचाया:
| में प्रकाशित: | Aging Cell |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley and Sons Inc.
2018
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052477/ https://ncbi.nlm.nih.gov/pubmed/29851234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12784 |
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