Mice with reduced expression of the telomere‐associated protein Ft1 develop p53‐sensitive progeroid traits

Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A‐ and B‐type lamins. These features suggest that Ft1 may be implicated in aging regulatory pathways. Here, we show that cells derived from hypomorp...

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Detaylı Bibliyografya
Yayımlandı:Aging Cell
Asıl Yazarlar: La Torre, Mattia, Merigliano, Chiara, Burla, Romina, Mottini, Carla, Zanetti, Giorgia, Del Giudice, Simona, Carcuro, Mariateresa, Virdia, Ilaria, Bucciarelli, Elisabetta, Manni, Isabella, Vinciguerra, Gianluca Rampioni, Piaggio, Giulia, Riminucci, Mara, Cumano, Ana, Bartolazzi, Armando, Vernì, Fiammetta, Soddu, Silvia, Gatti, Maurizio, Saggio, Isabella
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052474/
https://ncbi.nlm.nih.gov/pubmed/29635765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12730
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