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Modifying the Lantibiotic Mutacin 1140 for Increased Yield, Activity, and Stability

Mutacin 1140 belongs to the epidermin family of type AI lantibiotics. This family has a broad spectrum of activity against Gram-positive bacteria. The binding of mutacin 1140 to lipid II leads to the inhibition of cell wall synthesis. Pharmacokinetic experiments with type AI lantibiotics are general...

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Bibliografske podrobnosti
izdano v:Appl Environ Microbiol
Main Authors: Geng, Mengxin, Smith, Leif
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052277/
https://ncbi.nlm.nih.gov/pubmed/29776930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00830-18
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