Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction

Increased reactive oxygen species (ROS) formation may enhance matrix metalloproteinase (MMP)-2 activity and promote cardiovascular dysfunction. We show for the first time that MMP-2 is upstream of increased ROS formation and activates signaling mechanisms impairing redox balance. Incubation of vascu...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Prado, Alejandro F., Pernomian, Laena, Azevedo, Aline, Costa, Rute A.P., Rizzi, Elen, Ramos, Junia, Paes Leme, Adriana F., Bendhack, Lusiane M., Tanus-Santos, Jose E., Gerlach, Raquel F.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052251/
https://ncbi.nlm.nih.gov/pubmed/30029165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.07.005
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