Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria

The underexploited antibacterial target 1-deoxy-d-xyluose 5-phosphate (DXP) synthase catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (d-GAP). DXP is an essential intermediate in the biosynthesis of ThDP, pyridoxal phosphate, and isop...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: DeColli, Alicia A., Nemeria, Natalia S., Majumdar, Ananya, Gerfen, Gary J., Jordan, Frank, Freel Meyers, Caren L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052232/
https://ncbi.nlm.nih.gov/pubmed/29784878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001980
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