Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing

Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast cancer. It benefits nearly 75% of patients with estrogen receptor (ER)-positive breast cancer that receive this drug. Its effectiveness is mainly attributed to its capacity to function as an ER antagonist,...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Rouhimoghadam, Milad, Safarian, Shahrokh, Carroll, Jason S., Sheibani, Nader, Bidkhori, Gholamreza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050429/
https://ncbi.nlm.nih.gov/pubmed/30050469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00907
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