The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model

Genome reassortment in Lassa virus (LASV) has been reported in nature, but phenotypic consequences of this phenomenon are not well described. Here we characterize, both in vitro and in vivo, reassortment between 2 LASV strains: the prototypic 1976 Josiah strain and a more recently isolated 2015 Libe...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Welch, Stephen R., Scholte, Florine E. M., Albariño, César G., Kainulainen, Markus H., Coleman-McCray, JoAnn D., Guerrero, Lisa Wiggleton, Chakrabarti, Ayan K., Klena, John D., Nichol, Stuart T., Spengler, Jessica R., Spiropoulou, Christina F.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Cellular and Infection Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050391/
https://ncbi.nlm.nih.gov/pubmed/30050872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00240
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