Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease

Overexpression of interleukin-15 (IL-15) is linked with immunopathology of several autoimmune disorders including celiac disease. Here, we utilized an anti-human IL-15 antibody 04H04 (anti-IL-15) to reverse immunopathogenesis of celiac disease. Anti-IL-15 was administered to six gluten-sensitive rhe...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Sestak, Karol, Dufour, Jason P., Liu, David X., Rout, Namita, Alvarez, Xavier, Blanchard, James, Faldas, Anne, Laine, David J., Clarke, Adam W., Doyle, Anthony G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050360/
https://ncbi.nlm.nih.gov/pubmed/30050538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01603
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