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Isolated domains of recombinant human apo-metallothionein 1A are folded at neutral pH: a denaturant and heat-induced unfolding study using ESI-MS

Metallothioneins (MTs) are characterized by their high metal loading capacity, small molecular weight, and abundant cysteine residues. It has long been thought that metal-free, or apo-MT peptides were unstructured and only adopted as a distinct conformation upon forming the metal clusters, described...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Irvine, Gordon W., Korkola, Natalie, Stillman, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050192/
https://ncbi.nlm.nih.gov/pubmed/29858425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180592
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