Effect of a SGLT2 inhibitor on the systemic and intrarenal renin–angiotensin system in subtotally nephrectomized rats

We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin–angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD). Oral administration of the selective SGLT2 inhibitor, TA-1887 (10...

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Udgivet i:J Pharmacol Sci
Main Authors: Li, Lei, Konishi, Yoshio, Morikawa, Takashi, Zhang, Yifan, Kitabayashi, Chizuko, Kobara, Hideki, Masaki, Tsutomu, Nakano, Daisuke, Hitomi, Hirofumi, Kobori, Hiroyuki, Nishiyama, Akira
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050139/
https://ncbi.nlm.nih.gov/pubmed/29983235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphs.2017.10.006
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