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Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue

Discovering molecular probes that specifically recognize distinct amyloid structures is highly important for physiological studies of protein-misfolding diseases as well as for the development of diagnostic reagents and inhibitors of amyloid self-assembly. Here, we demonstrate an approach that allow...

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Pubblicato in:Chem Sci
Autori principali: Boehringer, Régis, Kieffer, Bruno, Torbeev, Vladimir
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049524/
https://ncbi.nlm.nih.gov/pubmed/30061991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01790e
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