A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is currently available for ADPKD. Here we identify the Hippo signaling effector YAP and its transcriptional target, c-Myc, as promot...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Cai, Jing, Song, Xuewen, Wang, Wei, Watnick, Terry, Pei, York, Qian, Feng, Pan, Duojia
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049514/
https://ncbi.nlm.nih.gov/pubmed/29891559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.315127.118
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