Inhibitory effect of esculetin on free-fatty-acid-induced lipid accumulation in human HepG2 cells through activation of AMP-activated protein kinase

This study aimed to determine the lipid-lowering effect of esculetin (6,7-dihydroxycoumarin), a coumarin derivative, using a cell model of steatosis induced by a mixture of free fatty acids (FFAs). Esculetin dose-dependently inhibited intracellular lipid accumulation by down-regulating the protein e...

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Vydáno v:Food Sci Biotechnol
Hlavní autoři: Park, Yeaji, Sung, Jeehye, Yang, Jinwoo, Ham, Hyeonmi, Kim, Younghwa, Jeong, Heon-Sang, Lee, Junsoo
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Food Science and Technology 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049482/
https://ncbi.nlm.nih.gov/pubmed/30263537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10068-017-0035-0
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