Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance

BACKGROUND: Falcipain-2a ([FP2a] PF3D7_1115700) is a Plasmodium falciparum cysteine protease and hemoglobinase. Functional FP2a is required for potent activity of artemisinin, and in vitro selection for artemisinin resistance selected for an FP2a nonsense mutation. METHODS: To investigate associatio...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Siddiqui, Faiza A, Cabrera, Mynthia, Wang, Meilian, Brashear, Awtum, Kemirembe, Karen, Wang, Zenglei, Miao, Jun, Chookajorn, Thanat, Yang, Zhaoqing, Cao, Yaming, Dong, Gang, Rosenthal, Philip J, Cui, Liwang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048984/
https://ncbi.nlm.nih.gov/pubmed/29659945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy188
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