Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

BACKGROUND: The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in vivo with copy number variation and mutations in the promoter region in pvcr...

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Vydáno v:Malar J
Hlavní autoři: Silva, Siuhelem Rocha, Almeida, Anne Cristine Gomes, da Silva, George Allan Villarouco, Ramasawmy, Rajendranath, Lopes, Stefanie Costa Pinto, Siqueira, André Machado, Costa, Gabriel Luíz, Sousa, Taís Nóbrega, Vieira, José Luiz Fernandes, Lacerda, Marcus Vinícius Guimarães, Monteiro, Wuelton Marcelo, de Melo, Gisely Cardoso
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048775/
https://ncbi.nlm.nih.gov/pubmed/30012145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2411-5
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