Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts

Platelets affect myocardial damage from ischemia/reperfusion. Redox-dependent sphingosine-1-phosphate production and release are altered in diabetic platelets. Sphingosine-1-phosphate is a double-edged sword for ischemia/reperfusion injury. Therefore, we aimed to verify whether: (1) human healthy- o...

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Vydáno v:Front Physiol
Hlavní autoři: Russo, Isabella, Femminò, Saveria, Barale, Cristina, Tullio, Francesca, Geuna, Stefano, Cavalot, Franco, Pagliaro, Pasquale, Penna, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048273/
https://ncbi.nlm.nih.gov/pubmed/30042694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00875
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