Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

Neuroinflammation plays a critical role in the pathogenesis of postoperative cognitive dysfunction (POCD) of the elderly patients. Receptor-interacting protein kinase1 (RIPK1) is a key molecular switch modulating inflammation, apoptosis and necroptosis. Here, we investigated whether inhibiting RIPK1...

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Udgivet i:Front Behav Neurosci
Main Authors: Duan, Shangchun, Wang, Xueqin, Chen, Gong, Quan, Chengxuan, Qu, Shuangquan, Tong, Jianbin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048190/
https://ncbi.nlm.nih.gov/pubmed/30042663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2018.00138
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