Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice

The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. I...

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Publicado en:Sci Rep
Main Authors: Yang, Chun, Larin, Andrei, McKenna, James T., Jacobson, Kenneth A., Winston, Stuart, Strecker, Robert E., Kalinchuk, Anna, Basheer, Radhika, Brown, Ritchie E.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048041/
https://ncbi.nlm.nih.gov/pubmed/30013200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29103-4
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