Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyzed with positional scanning using fluorogenic tetrapeptides...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Debela, Mekdes, Magdolen, Viktor, Skala, Wolfgang, Elsässer, Brigitta, Schneider, Eric L., Craik, Charles S., Biniossek, Martin L., Schilling, Oliver, Bode, Wolfram, Brandstetter, Hans, Goettig, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048020/
https://ncbi.nlm.nih.gov/pubmed/30013126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29058-6
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