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Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib

PURPOSE: Targeted hepatocellular carcinoma therapy was carried out to improve the efficacy of liver cancer treatment. The purpose of this study was to design an N-acetylgalactosamine (NAcGal) modified and pH sensitive doxorubicin (DOX) prodrug (NAcGal-DOX) for the construction of lipid nanoparticles...

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Publicat a:Drug Des Devel Ther
Autors principals: Duan, Wendu, Liu, Yan
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047861/
https://ncbi.nlm.nih.gov/pubmed/30034219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S166402
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