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Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy

BACKGROUND: Multidrug resistance is responsible for the poor outcome in breast cancer therapy. Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P) H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-del...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Li, Xin, Jia, Xiaoqian, Niu, Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047616/
https://ncbi.nlm.nih.gov/pubmed/30034236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S163929
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