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SHH E176/E177-Zn(2+) conformation is required for signaling at endogenous sites
Sonic hedgehog (SHH) is a master developmental regulator. In 1995, the SHH crystal structure predicted that SHH-E176 (human)/E177 (mouse) regulates signaling through a Zn(2+)-dependent mechanism. While Zn(2+) is known to be required for SHH protein stability, a regulatory role for SHH-E176 or Zn(2+)...
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| Publié dans: | Dev Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6047533/ https://ncbi.nlm.nih.gov/pubmed/28263766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2017.02.006 |
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