First-in-Human Randomized, Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector

BACKGROUND: Mosaic immunogens are bioinformatically engineered human immunodeficiency virus type 1 (HIV-1) sequences designed to elicit clade-independent coverage against globally circulating HIV-1 strains. METHODS: This phase 1, double-blinded, randomized, placebo-controlled trial enrolled healthy...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Baden, Lindsey R, Walsh, Stephen R, Seaman, Michael S, Cohen, Yehuda Z, Johnson, Jennifer A, Licona, J Humberto, Filter, Rachel D, Kleinjan, Jane A, Gothing, Jon A, Jennings, Julia, Peter, Lauren, Nkolola, Joseph, Abbink, Peter, Borducchi, Erica N, Kirilova, Marinela, Stephenson, Kathryn E, Pegu, Poonam, Eller, Michael A, Trinh, Hung V, Rao, Mangala, Ake, Julie A, Sarnecki, Michal, Nijs, Steven, Callewaert, Katleen, Schuitemaker, Hanneke, Hendriks, Jenny, Pau, Maria G, Tomaka, Frank, Korber, Bette T, Alter, Galit, Dolin, Raphael, Earl, Patricia L, Moss, Bernard, Michael, Nelson L, Robb, Merlin L, Barouch, Dan H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047429/
https://ncbi.nlm.nih.gov/pubmed/29669026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy212
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