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Strategic and Statistical Considerations on the QT Assessment of Volasertib

Volasertib is a selective cell cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinase (Plk). A potential for prolonged QT intervals was indicated with volasertib in preclinical studies and preliminary clinical data. As a result, electrocardiograms (ECGs) have...

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Detalhes bibliográficos
Publicado no:Ther Innov Regul Sci
Main Authors: Wallenstein, Gudrun, Walter, Beate, Fritsch, Holger, Taube, Tillmann
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047300/
https://ncbi.nlm.nih.gov/pubmed/29714574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2168479017739826
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