In Search of Selectivity in Inhibition of ADAM10

[Image: see text] The metalloproteinase ADAM10 has been reported as an important target for drug discovery in several human diseases. In this vein, (6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide (compound 1) has been report...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Mahasenan, Kiran V., Ding, Derong, Gao, Ming, Nguyen, Trung T., Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Chang, Mayland, Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047167/
https://ncbi.nlm.nih.gov/pubmed/30034605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00163
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