Dipeptide Prodrugs of the Glutamate Modulator Riluzole

[Image: see text] We have previously reported a prodrug strategy based on the marketed drug riluzole (2-amino-6-trifluoromethoxybenzothiazole), associated with the benefits of lower patient to patient variability of exposure and potentially once daily oral dosing, as opposed to the large variance an...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Pelletier, Jeffrey C., Chen, Suzie, Bian, Haiyan, Shah, Raj, Smith, Garry R., Wrobel, Jay E., Reitz, Allen B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047042/
https://ncbi.nlm.nih.gov/pubmed/30034613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00189
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