Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis

Progressive loss of tissue homeostasis is a hallmark of numerous age-related pathologies, including osteoarthritis (OA). Accumulation of senescent chondrocytes in joints contributes to the age-dependent cartilage loss of functions through the production of hypertrophy-associated catabolic matrix-rem...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Chuchana, Paul, Mausset-Bonnefont, Anne-Laure, Mathieu, Marc, Espinoza, Francisco, Teigell, Marisa, Toupet, Karine, Ripoll, Chantal, Djouad, Farida, Noel, Danièle, Jorgensen, Christian, Brondello, Jean-Marc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals 2018
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046234/
https://ncbi.nlm.nih.gov/pubmed/29920476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101481
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