A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

In metazoans, tissues experiencing proteotoxic stress induce “transcellular chaperone signaling” (TCS) that activates molecular chaperones, such as hsp-90, in distal tissues. How this form of inter-tissue communication is mediated to upregulate systemic chaperone expression and whether it can be uti...

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Udgivet i:Cell Rep
Main Authors: O’Brien, Daniel, Jones, Laura M., Good, Sarah, Miles, Jo, Vijayabaskar, M.S., Aston, Rebecca, Smith, Catrin E., Westhead, David R., van Oosten-Hawle, Patricija
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045774/
https://ncbi.nlm.nih.gov/pubmed/29949773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.093
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