PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer

Prostate-associated gene 4 (PAGE4) is an intrinsically disordered protein implicated in prostate cancer. The stress-response kinase homeodomain-interacting protein kinase 1 (HIPK1) phosphorylates two residues in PAGE4, serine 9 and threonine 51. Phosphorylation of these two residues facilitates the...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Lin, Xingcheng, Roy, Susmita, Jolly, Mohit Kumar, Bocci, Federico, Schafer, Nicholas P., Tsai, Min-Yeh, Chen, Yihong, He, Yanan, Grishaev, Alexander, Weninger, Keith, Orban, John, Kulkarni, Prakash, Rangarajan, Govindan, Levine, Herbert, Onuchic, José N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045464/
https://ncbi.nlm.nih.gov/pubmed/29758263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.05.011
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