Tautomeric-Dependent Lactam Cycloaddition with Nitrile Oxide: Facile Synthesis of 1,2,4-Oxadiazole[4,5-a]indolone Derivatives

[Image: see text] A concise, metal-free, and gram-scale strategy to convert indoline-2,3-diones to 1,2,4-oxadiazole[4,5-a]indolones through an improved [3 + 2] cycloaddition of α-ketone-lactam with nitrile oxides has been developed. The lactim form of the resonance structure of isatin in protic solv...

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Опубликовано в: :ACS Omega
Главные авторы: Jiang, Kun-Ming, Luesakul, Urarika, Zhao, Shu-Yue, An, Kun, Muangsin, Nongnuj, Neamati, Nouri, Jin, Yi, Lin, Jun
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2017
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044867/
https://ncbi.nlm.nih.gov/pubmed/30023685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00490
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