Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Vascular leakage is one of the salient characteristics of severe dengue. Nonstructural protein 1 (NS1) of dengue virus (DENV) can stimulate endothelial cells to secrete endothelial hyperpermeability factor, macrophage migration inhibitory factor (MIF), and the glycocalyx degradation factor heparanas...

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Publicado en:PLoS Pathog
Autores principales: Chen, Hong-Ru, Chao, Chiao-Hsuan, Liu, Ching-Chuan, Ho, Tzong-Shiann, Tsai, Huey-Pin, Perng, Guey-Chuen, Lin, Yee-Shin, Wang, Jen-Ren, Yeh, Trai-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044858/
https://ncbi.nlm.nih.gov/pubmed/29702687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007033
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