Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G-Quadruplex-Stabilizing Ligands with Improved Anticancer Activity

[Image: see text] Human telomeric G-quadruplex DNA stabilization has emerged as an exciting novel approach for anticancer drug development. In the present study, we have designed and synthesized three C(2)-symmetric bisubstituted bisbenzimidazole naphthalenediimide (NDI) ligands, ALI-C(3), BBZ-ARO,...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Sur, Souvik, Tiwari, Vinod, Sinha, Devapriya, Kamran, Mohammad Zahid, Dubey, Kshatresh Dutta, Suresh Kumar, Gopinatha, Tandon, Vibha
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044781/
https://ncbi.nlm.nih.gov/pubmed/30023623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00523
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