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Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that ar...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Mochel, Jonathan P., Jergens, Albert E., Kingsbury, Dawn, Kim, Hyun Jung, Martín, Martín G., Allenspach, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044282/
https://ncbi.nlm.nih.gov/pubmed/29234895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0178-1
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