Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target proteins. LUBAC consists of the catalytic HOIP subunit and two accessory subunits, HOIL-1L and SHARPIN. Interactions between the ubiquitin-associa...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Fujita, Hiroaki, Tokunaga, Akira, Shimizu, Satoshi, Whiting, Amanda L., Aguilar-Alonso, Francisco, Takagi, Kenji, Walinda, Erik, Sasaki, Yoshiteru, Shimokawa, Taketo, Mizushima, Tsunehiro, Ohki, Izuru, Ariyoshi, Mariko, Tochio, Hidehito, Bernal, Federico, Shirakawa, Masahiro, Iwai, Kazuhiro
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044281/
https://ncbi.nlm.nih.gov/pubmed/29694895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.112
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